Related Experiment Video

Updated: Jun 13, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

A case of Paget's disease in hemodialysis

G Cianciolo1, G La Manna, I Capelli

  • 1Nephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Bologna, Italy.

Clinical Nephrology
|April 28, 2010
PubMed

Insights

This case study details the first reported instance of Paget's disease in a hemodialysis patient. A combination therapy of clodronate, cinacalcet, and paracalcitol proved effective in managing this rare condition.

Area of Science:

  • Nephrology and Endocrinology
  • Bone Metabolism and Mineral Disorders

Background:

  • Paget's disease is a prevalent bone disorder characterized by excessive bone turnover.
  • Chronic kidney disease (CKD) significantly disrupts bone mineral metabolism, electrolyte balance, and parathyroid hormone (PTH) homeostasis.
  • The co-occurrence of Paget's disease and CKD presents unique clinical challenges.

Observation:

  • A hemodialysis patient presented with Paget's disease, a condition rarely seen in this population.
  • The patient also exhibited secondary hyperparathyroidism, a common complication in CKD.
  • This marks the first documented case of Paget's disease in a patient undergoing hemodialysis.

Findings:

  • A combined therapeutic approach using clodronate, cinacalcet, and paracalcitol was successfully implemented.
  • The 12-month follow-up demonstrated the safety and efficacy of this multi-drug regimen.
  • Treatment outcomes were assessed using standard bone turnover markers and levels of OPG, RANKL, IL-6, and MCSF.

Implications:

  • This study suggests a viable therapeutic strategy for managing Paget's disease in hemodialysis patients.
  • The findings highlight the importance of monitoring bone metabolism in CKD patients.
  • Further research into the combined effects of these agents on bone pathophysiology markers is warranted.

More Related Videos

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

Related Concept Videos

Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...