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Published on: June 22, 2015
Curcuma comosa improves learning and memory function on ovariectomized rats in a long-term Morris water maze test
Jian Su1, Kittisak Sripanidkulchai, J Michael Wyss
1Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Journal of Ethnopharmacology
|April 28, 2010
Summary
Curcuma comosa extract, similar to estrogen, improved spatial learning and memory in ovariectomized rats. This herbal treatment offers potential benefits for cognitive function in aging or postmenopausal individuals.
Area of Science:
- Neuroscience
- Pharmacology
- Ethnobotany
Background:
- Estrogen is known to enhance learning and memory in animal models and potentially in postmenopausal women.
- Curcuma comosa extract exhibits estrogenic-like effects, suggesting a potential role in cognitive function.
Purpose of the Study:
- To investigate the effects of Curcuma comosa extract on spatial learning and memory in ovariectomized rats.
- To compare the cognitive benefits of Curcuma comosa with those of estrogen.
Main Methods:
- Ovariectomized Wistar rats were treated with Curcuma comosa hexane extract (250 or 500 mg/kg) or 17beta-estradiol (10 microg/kg).
- Spatial learning and memory were assessed using the Morris water maze over 119 days.
Main Results:
- Ovariectomized rats showed significant memory impairment compared to controls.
- Both Curcuma comosa extract and estrogen treatment protected against cognitive decline.
- Higher doses of Curcuma comosa demonstrated a more pronounced protective effect on cognitive function.
Conclusions:
- Long-term administration of Curcuma comosa extract positively impacts learning and memory in rats.
- Curcuma comosa may serve as a potential therapeutic agent for cognitive enhancement.
