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Related Experiment Videos

Alterations in circulating lymphocyte number and function after circulation through colorectal carcinomas.

K M Rigg1, B K Shenton, I Brotherick

  • 1University Department of Surgery, Medical School, Newcastle upon Tyne, United Kingdom.

Surgery
|June 1, 1991
PubMed
Summary

Colorectal cancer alters immune cells, increasing natural killer (NK) cells but decreasing T-lymphocyte activation and proliferation in blood near the tumor. These findings suggest local tumor effects on immune function.

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Area of Science:

  • Immunology
  • Oncology
  • Surgical Research

Background:

  • Colorectal cancer (CRC) significantly impacts the tumor microenvironment.
  • Understanding the systemic effects of CRC on immune cells is crucial for effective treatment strategies.

Purpose of the Study:

  • To investigate the impact of colorectal tumors on circulating lymphocytes.
  • To compare immune cell populations and functions in blood supplying versus draining the tumor.

Main Methods:

  • Analysis of lymphocytes in arterial (supplying) and venous (draining) blood from 36 colorectal cancer patients undergoing resection.
  • Comparison with a control group of 16 patients.
  • Assessment of natural killer (NK) cell percentage and function, and T-lymphocyte activation and proliferation.

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Main Results:

  • Increased percentage of NK cells in venous blood draining the tumor (p = 0.001).
  • Decreased T-lymphocyte activation (p = 0.035) and proliferation (p = 0.002) in venous blood compared to arterial blood.
  • No significant differences observed in the control group.

Conclusions:

  • Colorectal cancer locally influences immune cells, characterized by an increase in NK cells and a decrease in T-cell function.
  • Therapeutic strategies to enhance antitumor immunity, potentially via the portal vein during surgery, should consider these immunosuppressive effects.