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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Open versus endovascular intervention for critical limb ischemia: a population-based study
David L Cull1, Eugene M Langan, Bruce H Gray
1Department of Surgery, Greenville Hospital System University Medical Center, University of South Carolina, Greenville, SC 29605, USA. Dcull@ghs.org
Endovascular therapy for critical limb ischemia (CLI) increased, but amputation rates remained unchanged. This shift to endovascular interventions necessitates more secondary procedures for limb salvage.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Public Health Outcomes
Background:
- Critical limb ischemia (CLI) is often treated with endovascular techniques.
- Assessing the impact of endovascular therapy on CLI and amputation rates in South Carolina over a decade is crucial.
Purpose of the Study:
- To evaluate the effectiveness of endovascular therapy in managing CLI.
- To compare amputation rates before and after the widespread adoption of endovascular procedures for CLI.
Main Methods:
- Retrospective analysis of CLI treatment outcomes in South Carolina.
- Comparison of patient data from 1996 (pre-endovascular era) and 2005 (endovascular era).
- Utilized ICD-9 codes to identify revascularization, amputation, and secondary procedures.
Main Results:
- Limb revascularization procedures increased by 33%, with a shift from 26% endovascular in 1996 to 51% in 2005.
- Amputation rates at 1 and 3 years post-revascularization showed no significant difference between the two eras (34% vs. 34% at 1 year; 43% vs. 40% at 3 years).
- The rate of secondary revascularization within the same year significantly increased from 8% in 1996 to 19% in 2005 (p < 0.001).
Conclusions:
- Despite an increase in endovascular procedures for CLI, overall amputation rates have not improved.
- The adoption of endovascular therapy has led to a higher requirement for repeat procedures to maintain limb salvage.
- Current endovascular approaches may necessitate more interventions to achieve outcomes comparable to traditional open surgery.
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