Related Experiment Video
Updated: Jun 13, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
[Deep brain stimulation for Parkinson's disease]
1Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany.
Abstract:
Deep brain stimulation (DBS) is an effective neurosurgical therapy for treatment of motor symptoms in Parkinson's disease (PD). DBS of the subthalamic nucleus (STN-DBS) leads to a significant reduction of hypokinetic and hyperkinetic symptoms and improvement in quality of life. STN-DBS is, however, associated with severe adverse effects including psychiatric symptoms, such as depression, apathy and increased suicidal tendencies. Pallidal DBS might be just as efficacious with fewer adverse effects. Future studies will prospectively compare the clinical effects of STN and pallidal DBS. Alternative targets for treatment of PD have to be considered including the pedunculopontine nucleus, thalamic CM/Pf complex and zona incerta.
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease l: Introduction
Parkinson Disease ll: Pathophysiology
Parkinson's Disease: Overview

