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Updated: Jun 13, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Islamic fasting and health.

Fereidoun Azizi¹

¹Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. azizi @ endocrine.ac.ir

Annals of Nutrition & Metabolism

|April 29, 2010

Summary

Ramadan fasting, a daily sunrise to sunset fast, is generally safe for healthy individuals. However, individuals with certain medical conditions, particularly diabetes, should consult physicians before fasting.

Area of Science:

Islamic practices and human physiology
Nutritional science and metabolic effects
Public health and preventive medicine

Background:

Ramadan involves daily fasting from sunrise to sunset for approximately 13-18 hours.
Fasting during Ramadan requires complete abstinence from food and liquids.
This review examines the health implications of Ramadan fasting.

Purpose of the Study:

To review the health-related aspects of Ramadan fasting.
To assess the physiological and metabolic effects of intermittent fasting during Ramadan.
To provide evidence-based recommendations for individuals observing Ramadan fasts.

Main Methods:

A comprehensive literature search was conducted using Medline and local Islamic journals.
Abstracts were retrieved from 1960 to 2009.

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113 selected articles were reviewed to gather detailed information.

Main Results:

Glucose homeostasis is maintained through pre-dawn meals and liver glycogen stores during Ramadan fasting.
Serum lipid changes are variable, influenced by diet quality, quantity, and weight fluctuations.
Ramadan fasting shows no adverse effects on cardiovascular, pulmonary, hepatic, renal, ocular, hematologic, endocrine, or neuropsychiatric functions.
While safe for well-controlled type 2 diabetics, it's not recommended for type 1, poorly controlled, or pregnant diabetics.

Conclusions:

Ramadan fasting is considered safe for the general healthy population.
Individuals with pre-existing medical conditions should seek medical advice before fasting.
Adherence to scientific recommendations is crucial for safe Ramadan fasting practices.