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Updated: Jun 13, 2026
11:32
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[From Pneumococcus to Pseudomonas: the antibacterial behaviour through the time].
1Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Universita di Siena, Italy.
Le Infezioni in Medicina
|April 29, 2010
Summary
Fluoroquinolones are widely used antibiotics, but their extensive application has driven bacterial resistance. Despite this, their overall antibacterial effectiveness remains high after decades of use.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Fluoroquinolones are broad-spectrum antibiotics frequently used in both community and hospital settings.
- Their efficacy, tolerability, and oral formulation contribute to widespread global usage.
- Extensive use has exerted significant selective pressure, leading to the emergence of resistant bacterial strains.
Purpose of the Study:
- To assess the sustained antibacterial activity of fluoroquinolones.
- To evaluate the impact of widespread use and resistance development on fluoroquinolone efficacy.
Main Methods:
- Review of existing literature on fluoroquinolone usage and resistance patterns.
- Analysis of antibacterial activity data for first-generation and later-generation fluoroquinolones.
Main Results:
- Worldwide use of fluoroquinolones has led to significant selective pressure for resistance.
- Despite resistance, the overall antibacterial activity of fluoroquinolones, including older and newer agents, remains largely high.
Conclusions:
- Fluoroquinolones continue to be effective antimicrobial agents.
- Ongoing monitoring of resistance is crucial to preserve the clinical utility of fluoroquinolones.
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