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Updated: Jun 13, 2026

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
Published on: March 29, 2024
Pharmacoepigenetics in heart failure
Irene Mateo Leach1, Pim van der Harst, Rudolf A de Boer
1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands. i.v.mateo.leach@thorax.umcg.nl
Abstract:
Epigenetics studies inheritable changes of genes and gene expression that do not concern DNA nucleotide variation. Such modifications include DNA methylation, several forms of histone modification, and microRNAs. From recent studies, we know not only that genetic changes account for heritable phenotypic variation, but that epigenetic changes also play an important role in the variation of predisposition to disease and to drug response. In this review, we discuss recent evidence of epigenetic changes that play an important role in the development of cardiac hypertrophy and heart failure and may dictate response to therapy.
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