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Updated: Jun 13, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
Published on: February 13, 2026
Early human bone response to laser metal sintering surface topography: a histologic report
Carlo Mangano1, Adriano Piattelli, Susana d'Avila
1University of Varese, Italy.
Abstract:
This histologic report evaluated the early human bone response to a direct laser metal sintering implant surface retrieved after a short period of healing. A selective laser sintering procedure using a Ti-6Al-4V alloy powder with a particle size of 25-45 microm prepared this surface topography. One experimental microimplant was inserted into the anterior mandible of a patient during conventional implant surgery of the jaw. The microimplant and surrounding tissues were removed after 2 months of unloaded healing and were prepared for histomorphometric analysis. Histologically, the peri-implant bone appeared in close contact with the implant surface, whereas marrow spaces could be detected in other areas along with prominently stained cement lines. The mean of bone-to-implant contact was 69.51%. The results of this histologic report suggest that the laser metal sintering surface could be a promising alternative to conventional implant surface topographies.

