Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

In vivo 19F MRI for Cell Tracking

In vivo ¹⁹F MRI for Cell Tracking

Published on: November 25, 2013

(19)F MRI for quantitative in vivo cell tracking.

Mangala Srinivas¹, Arend Heerschap, Eric T Ahrens

¹Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

Trends in Biotechnology

|April 30, 2010

Summary

Fluorine-19 magnetic resonance imaging (¹⁹F MRI) offers direct, quantitative cell tracking for cellular therapies. This advanced imaging technique is nearing clinical application for monitoring cell delivery and dosage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving magnetic field homogeneity in prostate MR imaging and spectroscopy using an add-on local external shim coil array.

Magma (New York, N.Y.)·2025

Same author

Muscle imaging in facioscapulohumeral muscular dystrophy research: A scoping review and expert recommendations.

Neuromuscular disorders : NMD·2025

Same author

Simultaneous Concentration and T<sub>2</sub> Mapping of Brain Metabolites by Fast Multi-Echo Spectroscopic Imaging.

NMR in biomedicine·2025

Same author

Diffusion-weighted MR spectroscopy of the prostate.

Magnetic resonance in medicine·2024

Same author

Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats.

Toxicology mechanisms and methods·2023

Same author

A multivariate curve resolution analysis of multicenter proton spectroscopic imaging of the prostate for cancer localization and assessment of aggressiveness.

NMR in biomedicine·2023

Area of Science:

Biomedical Imaging
Cellular Therapy Monitoring
Radiochemistry

Background:

Noninvasive imaging, particularly magnetic resonance imaging (MRI), is crucial for monitoring cellular therapies like stem cell transplants and dendritic cell vaccines.
Current methods face challenges in accurate cell quantification and localization.
Fluorine-19 (¹⁹F) compounds offer unique advantages for MRI due to their direct detectability and quantification capabilities.

Purpose of the Study:

To review the application of ¹⁹F MRI for cell tracking in the context of cellular therapeutics.
To discuss the potential clinical translation of ¹⁹F MRI technology.
To highlight advancements in intracellular ¹⁹F labeling, cell labeling techniques, and in vivo quantification.

Main Methods:

More Related Videos

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Monitoring Dendritic Cell Migration using ¹⁹F / ¹H Magnetic Resonance Imaging

Published on: March 20, 2013

Tracking Mouse Bone Marrow Monocytes In Vivo

Tracking Mouse Bone Marrow Monocytes In Vivo

Published on: February 27, 2015

Related Experiment Videos

Last Updated: Jun 13, 2026

In vivo 19F MRI for Cell Tracking

In vivo ¹⁹F MRI for Cell Tracking

Published on: November 25, 2013

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging

Monitoring Dendritic Cell Migration using ¹⁹F / ¹H Magnetic Resonance Imaging

Published on: March 20, 2013

Tracking Mouse Bone Marrow Monocytes In Vivo

Tracking Mouse Bone Marrow Monocytes In Vivo

Published on: February 27, 2015

Review of existing literature on ¹⁹F MRI for cell tracking.

Discussion of intracellular ¹⁹F labeling strategies and cell labeling protocols.

Analysis of in vivo quantification methods for ¹⁹F MRI.

Main Results:

¹⁹F MRI enables direct detection and unambiguous quantification of labeled cells, surpassing limitations of metal-based contrast agents.
Recent developments have significantly advanced in vivo cell quantification using ¹⁹F MRI.
The clinical use of ¹⁹F compounds and growing interest in cellular therapies accelerate the clinical application of ¹⁹F imaging.

Conclusions:

¹⁹F MRI is a promising noninvasive imaging modality for monitoring cellular therapies, offering direct cell detection and quantification.
The technology is advancing rapidly towards clinical application for cell tracking, dosage optimization, and delivery verification.
Further research into ¹⁹F labels, labeling techniques, and clinical validation will enhance its utility in regenerative medicine.