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Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

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Intravascular imaging with a storage phosphor detector.

Polad M Shikhaliev¹, Peter Petrek, Kenneth L Matthews

¹Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, USA. pshikhal@lsu.edu

Physics in Medicine and Biology

|April 30, 2010

Summary

This summary is machine-generated.

This study developed an intravascular imaging system using a storage phosphor detector to visualize vulnerable coronary artery plaques with F18-FDG. The prototype detector shows potential for clinical use in detecting arterial disease.

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Area of Science:

Medical Imaging
Cardiovascular Technology
Radiochemistry

Background:

Vulnerable plaques in coronary arteries pose a significant risk for cardiovascular events.
Current imaging methods have limitations in detecting and characterizing these plaques.
Fluorodeoxyglucose (F18-FDG) positron emission tomography (PET) can identify metabolically active, vulnerable plaques.

Purpose of the Study:

To develop and evaluate an intravascular positron imaging system for detecting vulnerable coronary artery plaques.
To assess the feasibility of using a storage phosphor detector for in-artery imaging.
To determine the system's sensitivity, spatial resolution, and imaging capabilities in a phantom model.

Main Methods:

A prototype intravascular detector (55 mm length, 2 mm diameter) utilizing a flexible storage phosphor tube was constructed.
A laser-based system was integrated to erase X-ray fluoroscopy signals before positron imaging.
A heart phantom with coronary arteries containing F18-FDG-labeled plaques was used for testing the detector's performance.

Main Results:

The system successfully visualized vulnerable plaques with area activities as low as 1.2 nCi mm(-2) in a phantom model.
The detector imaged the internal surface of coronary vessels (50 mm length, 360° circumference) with a spatial resolution of 0.6-1.2 mm FWHM.
The system demonstrated flexibility, reusability, and near real-time imaging capabilities.

Conclusions:

The developed intravascular storage phosphor detector shows promise for imaging human coronary artery plaques.
The system offers the necessary sensitivity, spatial resolution, and flexibility for potential clinical applications.
Future research will focus on reducing detector size and conducting in vivo animal studies.