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Targeting one-carbon metabolism for cancer immunotherapy
Xinxin Ren1,2,3,4, Xiang Wang5, Guowan Zheng1,2,3
1Department of Head and Neck Surgery, Otolaryngology & Head and Neck Center, Cancer Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Clinical and Translational Medicine
|January 27, 2024
Summary
Targeting one-carbon (1C) metabolism is crucial for cancer immunotherapy. This review explores 1C metabolism pathways, enzymes, and inhibitors for enhancing cancer treatment and patient outcomes.
Area of Science:
- Biochemistry
- Oncology
- Immunology
Background:
- One-carbon (1C) metabolism is vital for cellular processes like nucleotide synthesis, amino acid metabolism, and epigenetic maintenance.
- 1C metabolism is recognized as a hallmark of cancer, fueling rapid cancer cell proliferation.
- Dysregulation of 1C metabolism is implicated in cancer progression and response to therapy.
Purpose of the Study:
- To review the critical role of one-carbon (1C) metabolism in cancer immunotherapy.
- To elucidate the function of 1C metabolism pathways and enzymes in the context of cancer immunotherapy.
- To summarize inhibitors targeting 1C metabolism and their therapeutic potential in cancer immunotherapy.
Main Methods:
- Comprehensive literature review focusing on one-carbon (1C) metabolism and cancer immunotherapy.
- Analysis of key 1C metabolic pathways and their enzymes in cancer.
- Evaluation of inhibitors targeting 1C metabolism for immunotherapeutic applications.
Main Results:
- One-carbon (1C) metabolism pathways and enzymes significantly influence cancer immunotherapy efficacy.
- Inhibitors targeting 1C metabolism demonstrate potential as adjuncts to cancer immunotherapy.
- 1C metabolism can serve as a biomarker for predicting immunotherapy response and immune-related adverse events.
Conclusions:
- Targeting one-carbon (1C) metabolism presents a promising strategy for enhancing cancer immunotherapy.
- Further research is needed to overcome challenges and optimize clinical application of 1C metabolism-targeted therapies.
- Integrating 1C metabolism modulation into cancer treatment regimens holds potential for improved patient outcomes.
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