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The kidney in respiratory failure and mechanical ventilation
1UCD School of Medicine and Medical Science, Catherine McAuley Centre, Mater Misericordiae University Hospital, Dublin, Ireland.
Contributions to Nephrology
|April 30, 2010
Summary
Acute lung injury (ALI) can cause kidney damage through ventilator-induced kidney injury. This review explores the harmful interactions between lungs and kidneys in critical illness, highlighting ventilator-induced kidney injury
Area of Science:
- Critical care medicine
- Nephrology
- Pulmonology
Background:
- Acute lung injury (ALI) and acute kidney injury (AKI) are common in critical illness.
- Both injuries often coexist with systemic inflammatory response syndrome, shock, and multiple organ dysfunction.
- Emerging evidence reveals detrimental bidirectional organ crosstalk between lungs and kidneys.
Purpose of the Study:
- To review the evidence of lung-kidney crosstalk in critical illness.
- To focus on the role of ventilator-induced kidney injury (VIKI) in AKI pathogenesis in ALI patients.
Main Methods:
- Literature review of emerging evidence on organ crosstalk.
- Focus on studies investigating ventilator-induced kidney injury.
- Analysis of the pathogenesis of AKI in ALI patients.
Main Results:
- Ventilator settings can directly impact kidney function.
- ALI can exacerbate or initiate kidney injury through various mechanisms.
- Bidirectional crosstalk contributes to overall organ dysfunction.
Conclusions:
- Ventilator-induced kidney injury is a significant contributor to AKI in ALI patients.
- Understanding lung-kidney interactions is crucial for managing critical illness.
- Further research into mitigating VIKI is warranted.
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