Related Experiment Video
Updated: Jun 13, 2026
08:14
Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor
Published on: May 1, 2014
Epithelial stem/progenitor cells in the embryonic mouse submandibular gland
Frontiers of Oral Biology
|April 30, 2010
Summary
Researchers identified salivary epithelial stem/progenitor cells in embryonic mouse glands. Growth factors influencing development may also impact cell fate, paving the way for salivary tissue regeneration therapies.
Area of Science:
- Developmental Biology
- Regenerative Medicine
- Stem Cell Biology
Background:
- Salivary gland organogenesis relies on epithelial stem/progenitor cells for development.
- Understanding embryonic salivary gland stem/progenitor cells is crucial for regenerative therapies.
- Current research primarily focuses on postnatal salivary gland stem cells.
Purpose of the Study:
- To investigate the existence and characteristics of stem/progenitor cells in embryonic mouse salivary glands.
- To explore the influence of growth factors on early developmental lineages within the salivary epithelium.
- To lay the groundwork for future autologous stem cell therapies for salivary tissue regeneration.
Main Methods:
- Literature review of stem/progenitor cell populations in other developing organs.
- Comparative analysis to identify potential similar cell populations in mouse submandibular glands.
- Experimental approach using growth factors to assess transcriptional impact on salivary epithelial lineages.
Main Results:
- Preliminary evidence suggests the presence of salivary epithelial stem/progenitor populations in embryonic glands.
- Growth factors known to influence epithelial morphogenesis may also affect cell fate decisions.
- Identified potential transcriptional impacts of growth factors on early salivary gland development.
Conclusions:
- Salivary epithelial stem/progenitor cells are likely present during embryonic development.
- Growth factors play a role in directing cell fate decisions in the developing salivary gland.
- Further research into signaling networks is needed to develop therapeutic strategies for salivary tissue regeneration.
Related Concept Videos
01:23Renewal of Intestinal Stem Cells
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
01:33Adult Stem Cells
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
01:06Multipotency and Niche of Bulge Stem Cell
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...