Related Experiment Video
Updated: Jun 13, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Role of nitric oxide in regulating cardiac electrophysiology
1School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
Abstract:
Despite the explosion of new information on nitric oxide (NO), important questions about its role in regulating cardiac electrophysiology remain unanswered. Recent in vitro and in vivo animal studies have discovered a number of new electrophysiological properties of NO, some of which may contribute to a reduction in fatal arrhythmias induced by acute myocardial ischemia. This review summarizes the influences of NO on heart rate, atrioventricular conduction, ventricular repolarization and the development of ventricular arrhythmias during acute myocardial ischemia.
More Related Videos
08:23Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
06:40Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
Related Concept Videos
Nitric Oxide Signaling Pathway
Pathophysiology of Cardiac Performance
Electrophysiology of Normal Cardiac Rhythm
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Regulation of Heart Rates
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...