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Updated: Jun 13, 2026

Fabrication and Testing of Photonic Thermometers
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Fabrication and Testing of Photonic Thermometers

Published on: October 24, 2018

Microfluidic Photonic Integrated Circuits.

Sung Hwan Cho1, Jessica Godin2, Chun Hao Chen3

  • 1Materials Sci. & Eng. Program, University of California, San Diego, La Jolla, CA, USA.

Optoelectronic Materials and Devices
|September 28, 2011
PubMed
Summary
This summary is machine-generated.

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We developed an inexpensive, portable lab-on-a-chip flow cytometer integrating microfluidics, photonics, and acoustics. This system enables high-throughput, low-power fluorescence-activated cell sorting (FACS) for potential point-of-care diagnostics.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Photonics

Background:

  • Traditional flow cytometry is expensive and complex, limiting its accessibility.
  • Point-of-care diagnostics require portable, low-cost, and reliable analytical devices.

Purpose of the Study:

  • To develop an integrated, inexpensive, and portable lab-on-a-chip flow cytometer.
  • To enable high-throughput fluorescence-activated cell sorting (FACS) in a compact system.

Main Methods:

  • Integration of microfluidics, on-chip photonics (lenses, waveguides), and acoustics.
  • Real-time signal detection, amplification, and closed-loop control using FPGA.
  • Piezoelectric actuation for targeted sample sorting.

Main Results:

Keywords:
FACSFlow CytometryMicrofluidicsOn-chip opticsPhotonicsSensor

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  • Demonstrated a lab-on-a-chip system with integrated microfluidics, photonics, and acoustics.
  • Achieved high-throughput (1-10kHz), low-power (<1mW) operation for FACS.
  • Developed a real-time, closed-loop control system for precise sample handling.

Conclusions:

  • The developed system offers a portable and inexpensive solution for flow cytometry.
  • Potential for use as a point-of-care diagnostic device in resource-limited settings.
  • Synergistic integration of microfluidics, photonics, and acoustics enables advanced on-chip analysis.