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Global and cardiovascular mortality and risk factors in patients under hemodialysis treatment

Fátima Aparecida A Almeida1, Felipe Carrhá Machado, José Andrade Moura

  • 1Escola Bahiana de Medicina e Saúde Pública, BA, Brasil.

Arquivos Brasileiros De Cardiologia
|April 30, 2010
PubMed

Insights

Patients on hemodialysis face high mortality rates. Key risk factors include older age, low hemoglobin, and elevated blood glucose, highlighting the need for targeted interventions.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Hemodialysis patients experience elevated global and cardiovascular mortality rates.
  • Understanding these mortality rates is crucial for improving patient outcomes.

Purpose of the Study:

  • To assess global and cardiovascular mortality in hemodialysis patients.
  • To identify independent risk factors contributing to mortality in this population.

Main Methods:

  • An observational, prospective study involving 334 hemodialysis patients over three years.
  • Survival analysis using the Kaplan-Meier method.
  • Risk factor identification through bivariate and multivariate Cox regression analysis.

Main Results:

  • Global mortality was 21.6% and cardiovascular mortality was 41.7%.
  • Independent risk factors for mortality included age over 60, hemoglobin levels below 9 g/dL, and fasting glucose over 126 mg/dL.
  • Lower urea removal rate (Kt/V < 1.2) was associated with non-cardiovascular death.

Conclusions:

  • Hemodialysis patients have a high risk of both global and cardiovascular mortality.
  • Age, low hemoglobin, and high fasting glucose are significant independent risk factors.
  • Optimizing dialysis efficiency (Kt/V) is important for reducing non-cardiovascular mortality.
Abstract

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