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Related Experiment Video

Updated: Jun 13, 2026

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
10:37

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

[Remodeling pattern and ventricular function in rats exposed to cigarette smoke].

Paula S Azevedo1, Marcos F Minicucci, Beatriz B Matsubara

  • 1Faculdade de Medicina de Botucatu, UNESP, Botucatu, SP, Brasil.

Arquivos Brasileiros De Cardiologia
|April 30, 2010
PubMed
Summary

Cigarette smoke exposure in rats leads to various cardiac remodeling patterns. Increased left ventricular wall thickness is a key predictor of ventricular dysfunction in this model.

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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
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Published on: October 22, 2020

Area of Science:

  • Cardiovascular Research
  • Toxicology
  • Animal Models

Background:

  • The impact of cigarette smoke exposure on cardiac remodeling patterns in rats remains unclear.
  • Understanding these patterns is crucial for modeling smoking-related cardiovascular diseases.

Purpose of the Study:

  • To investigate the prevalence of different cardiac geometry patterns in rats exposed to cigarette smoke.
  • To determine the relationship between these remodeling patterns and ventricular function.

Main Methods:

  • 47 smoking rats were categorized by echocardiogram-assessed cardiac geometry: normal, concentric remodeling, concentric hypertrophy, and eccentric hypertrophy.
  • Analysis included mass index and relative wall thickness to classify patterns.

Main Results:

  • 51% of rats showed a normal pattern, 32% eccentric hypertrophy, 13% concentric hypertrophy, and 4% concentric remodeling.
  • Eccentric hypertrophy and normal groups had lower ejection fraction and fractional shortening than concentric hypertrophy.
  • Increased relative left ventricular wall thickness predicted ventricular dysfunction (p<0.001).

Conclusions:

  • Rats exposed to cigarette smoke exhibit diverse cardiac remodeling patterns.
  • Elevated left ventricular wall thickness is a significant predictor of ventricular dysfunction in this smoking rat model.