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Plasma lipid and lipoprotein levels in childhood
1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Insights
Normal plasma lipid and lipoprotein levels in American youth are documented. These reference ranges aid in identifying children at risk for adult cardiovascular diseases (CAD) or inherited lipid disorders.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Health
- Clinical Lipidology
Background:
- Plasma lipid and lipoprotein levels are crucial indicators of cardiovascular health.
- Established normal distributions exist for these levels in American children and adolescents.
- These distributions serve as essential benchmarks for clinical assessment.
Purpose of the Study:
- To highlight the importance of documented normal plasma lipid and lipoprotein distributions in pediatric populations.
- To provide guidelines for identifying children at risk for adult cardiovascular disease (CAD).
- To assist in diagnosing inherited dyslipoproteinemias associated with premature CAD.
Main Methods:
- Review and synthesis of existing data on normal plasma lipid and lipoprotein distributions in American children and adolescents.
- Establishment of reference ranges based on documented population data.
- Application of these ranges as diagnostic guidelines.
Main Results:
- Normal distributions for plasma lipid and lipoprotein levels in American children and adolescents are well-established.
- These documented values provide a basis for risk stratification.
- Guidelines are available for identifying at-risk individuals.
Conclusions:
- The documented normal distributions of plasma lipid and lipoprotein levels are vital clinical tools.
- These guidelines aid in the early diagnosis of children at risk for future cardiovascular disease.
- They are instrumental in detecting inherited lipid disorders linked to premature CAD.
Abstract:
The normal distributions of plasma lipid and lipoprotein levels in American children and adolescents are well-documented. These values can be used as working guidelines for the diagnosis of children felt to be at high risk for CAD in adulthood and those who may be suspected of having one of the inherited disorders or dyslipoproteinemias associated with premature CAD in adulthood.