Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excitation Spectra of the ^{12}C(p,d) Reaction near the η^{'}-Meson Emission Threshold Measured in Coincidence with High-Momentum Protons.

Physical review letters·2026
Same author

Sarcopenia and self-reported markers of physical frailty in patients with osteoporosis.

Archives of osteoporosis·2024
Same author

The effect of 30 min of supine rest on plasma renin concentrations in paediatric patients.

Acta paediatrica (Oslo, Norway : 1992)·2024
Same author

Nutritional status as independent prognostic factor of outcome and mortality until five years after hip fracture: a comprehensive prospective study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2024
Same author

Clinical practice guidelines for perioperative care in bariatric surgery 2023: Adapted ERAS (enhanced recovery after surgery) guidelines with consensual voting of the working group of the Joint Bariatric and Metabolic Surgery Section of the Czech Surgery….

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2024
Same author

Effect of 12-months testosterone replacement therapy on bone mineral density and markers of bone turnover in testicular cancer survivors - results from a randomized double-blind trial.

Acta oncologica (Stockholm, Sweden)·2023

Related Experiment Video

Updated: Jun 13, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Parathyroid hormone and bone healing.

M Ellegaard1, N R Jørgensen, P Schwarz

  • 1Research Center of Aging and Osteoporosis, Department of Medicine, Copenhagen University Hospital Glostrup, Nordre Ringvej, 2600, Glostrup, Denmark. marlar04@glo.regionh.dk

Calcified Tissue International
|April 30, 2010
PubMed
Summary

Parathyroid hormone (PTH) shows promise for accelerating fracture healing, particularly in at-risk groups. Early clinical trials suggest PTH may offer a new pharmacological treatment for non-union and impaired bone healing.

More Related Videos

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
07:53

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Related Experiment Videos

Last Updated: Jun 13, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
07:53

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Area of Science:

  • Orthopedics
  • Endocrinology
  • Pharmacology

Background:

  • Fracture healing is complex, with high rates of non-union in elderly, osteoporotic, malnourished individuals, and post-menopausal women.
  • Current treatments for impaired fracture healing are limited, creating a need for pharmacological interventions.
  • Parathyroid hormone (PTH) is an approved osteoporosis drug with potential anabolic effects on bone.

Purpose of the Study:

  • To review the evidence supporting parathyroid hormone's (PTH) potential in promoting fracture healing.
  • To explore the mechanisms by which PTH may enhance bone healing.
  • To provide recommendations for clinical use and testing of PTH for impaired fracture healing.

Main Methods:

  • Review of animal studies investigating PTH's effect on fracture healing in various models of impaired healing (aging, estrogen withdrawal, malnutrition).
  • Analysis of studies examining PTH's efficacy at both cancellous and cortical bone sites.
  • Evaluation of the first randomized, controlled clinical trial on PTH for fracture healing.

Main Results:

  • Animal studies demonstrate expedited fracture healing with PTH treatment, even under conditions of impaired healing.
  • PTH appears effective for both osteoporotic and non-osteoporotic fractures at various bone sites.
  • PTH may mitigate age-related delays in fracture healing, and initial clinical trials show possible benefits.

Conclusions:

  • Parathyroid hormone (PTH) shows significant potential as a pharmacological treatment to enhance fracture healing.
  • PTH's anabolic properties and demonstrated efficacy in preclinical models warrant further clinical investigation.
  • Recommendations for clinical testing and application of PTH in treating impaired fracture healing are needed.