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Updated: Jun 13, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Systemic lupus erythematosus].
Dusanka Martinović Kaliterna1, Mislav Radić, Ilza Salamunić
1Odsjek za klinicku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinicki bolnicki centar Split, Soltanska 1, 21000 Split.
Reumatizam
|May 1, 2010
Summary
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease affecting connective tissues, primarily in young women. Diagnosis relies on clinical and serological markers, with treatment involving corticosteroids and other immunosuppressants for severe cases.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Context:
- Systemic lupus erythematosus (SLE) is a chronic, multisystem inflammatory disease of unknown etiology.
- It predominantly affects young women and can impact joints, kidneys, serous membranes, and blood vessels.
Purpose:
- To outline the diagnostic criteria for SLE.
- To describe the management strategies for severe, active SLE.
Summary:
- Diagnosis of SLE necessitates meeting specific clinical and serological criteria.
- Management of severe active SLE typically involves corticosteroids, hydroxychloroquine, and potentially immunosuppressants.
Impact:
- Provides a concise overview of SLE diagnosis and treatment.
- Highlights key considerations for clinicians managing patients with SLE.
- Emphasizes the chronic and potentially severe nature of the disease.
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