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Updated: Jun 13, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Systemic lupus erythematosus and the complement system].
Dusanka Martinović Kaliterna1, Jadranka Morović Vergles, Mislav Radić
1Odsjek za klinicku imunologiju i reumatologiju, Klinika za unutarnje bolesti Klinicki bolnicki centar Split, Soltanska 1, 21000 Split.
Reumatizam
|May 1, 2010
Summary
The complement system protects the body but its dysregulation causes tissue damage. Complement deficiency increases infection risk and autoimmune diseases like systemic lupus erythematosus (SLE).
Area of Science:
- Immunology
- Infectious Diseases
- Autoimmunity
Context:
- The complement system is a crucial part of both innate and adaptive immunity.
- Its dysregulation is linked to tissue damage and increased susceptibility to infections.
- Complement deficiency is associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE).
Purpose:
- To highlight the dual role of the complement system in immune defense and disease pathogenesis.
- To emphasize the clinical significance of complement dysregulation and deficiency.
- To establish the link between complement levels and the activity of SLE and secondary antiphospholipid syndrome (APS).
Summary:
- The complement system provides essential protective functions within the immune system.
- Imbalances in the complement system can lead to tissue damage and predispose individuals to infections.
- Deficiencies in complement are strongly linked to the development of autoimmune conditions, notably SLE, where complement levels serve as indicators of disease activity.
Impact:
- Understanding complement's role is vital for diagnosing and managing autoimmune and infectious diseases.
- Lowered complement levels can serve as a biomarker for SLE and secondary APS activity.
- Further research into complement modulation may offer therapeutic strategies for related disorders.
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