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Updated: Jun 13, 2026
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Enhanced reactivity to malondialdehyde-modified proteins by systemic lupus erythematosus autoantibodies
R Ben Mansour1, S Lassoued, A Elgaied
1Unit of Biotechnology and Pathology, Higher Institute of Biotechnology of Sfax, Tunisia. riadhbm2004@yahoo.fr
Objective:
Evaluation of the reactivity of autoantibodies of systemic lupus erythematosus (SLE) patients directed against malondialdehyde (MDA)-modified catalase, superoxide dismutase (SOD), and different Hep2 protein fractions (hydrophobic, hydrophilic, and nuclear).
Method:
Thiol groups and MDA-protein adducts were first assessed among 65 SLE patients and 60 healthy controls. Then, the reactivities of SLE immunoglobulin (Ig)G autoantibodies towards MDA-modified and unmodified proteins were compared using a standard enzyme-linked immunosorbent assay (ELISA).
Results:
An increase in the levels of MDA-modified proteins and a decrease in the concentration of thiol groups among SLE patients (p < 0.05) were observed. IgG circulating autoantibodies in the sera of SLE patients exhibited a significant enhanced reactivity (p < 0.05) against catalase and SOD-modified proteins. The same data were observed in the different protein fractions extracted from cultured cells (p < 0.05).
Conclusion:
These data reinforce the role of oxidative stress and especially lipid peroxidation products in the progression of SLE disease.
