Related Experiment Video
Updated: Jun 13, 2026

In vitro Cannabis Exposures of Lung Epithelial Cells at the Air-Liquid Interface
Published on: June 20, 2025
Water-soluble organic solubilizers for in vitro drug delivery studies with respiratory epithelial cells: selection
Chris MacDonald1, Wendy Lyzenga, Di Shao
1Biopharmaceutics and Drug Delivery Laboratory, College of Pharmacy, Faculty of Health Professions, Dalhousie University, Halifax, NS, Canada, B3H 3J.
Abstract:
The aim of this study was to use different toxicity indices to investigate the effect of N, N-Dimethylacetamide (DMA), Polyethylene glycol 400 (PEG 400), Methyl-Pyrrolidone/aromatic hydrocarbon (MPH), Cremophor((R)) EL, and Dimethylsulfoxide (DMSO) on Calu-3 cells. Membrane perturbation and cytotoxicity were investigated using lactate dehydrogenase (LDH), 3-[4, 5-Dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolinium bromide (MTT), transepithelial electrical resistance (TEER) assessment, sodium fluorescein (SF) permeation, and phalloidin actin staining. The MDH activity of cells treated with DMSO (
More Related Videos
09:29An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
08:59An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
Related Concept Videos
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
In Vitro Drug Dissolution: Alternative Methods
Bioavailability Enhancement: Drug Solubility Enhancement