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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jun 13, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Comorbidities in psoriasis patients.

Noori Kim1, Breck Thrash, Alan Menter

  • 1University of Texas Southwestern, Dallas, TX.

Seminars in Cutaneous Medicine and Surgery
|May 1, 2010
PubMed
Summary
This summary is machine-generated.

Psoriasis patients often experience numerous comorbid conditions due to shared immune-mediated pathways. Comprehensive, multidisciplinary care is essential for managing this complex inflammatory disorder and its related health issues.

Related Experiment Videos

Last Updated: Jun 13, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Dermatology
  • Immunology
  • Internal Medicine

Background:

  • Psoriasis is a chronic inflammatory condition affecting 2% of the population.
  • Psoriatic patients exhibit a higher prevalence of comorbidities.
  • These include obesity, metabolic syndrome, cardiovascular disease, psoriatic arthritis, autoimmune disorders, psychiatric conditions, liver disease, smoking, malignancy, COPD, sleep apnea, and alcohol abuse.

Purpose of the Study:

  • To review the spectrum of comorbidities associated with psoriasis.
  • To explore the shared immune-mediated pathogenesis underlying psoriasis and its comorbidities.
  • To emphasize the need for a multidisciplinary approach in managing psoriatic disease.

Main Methods:

  • Literature review of studies on psoriasis comorbidities.
  • Analysis of overlapping pathophysiological mechanisms.
  • Synthesis of evidence supporting integrated patient care.

Main Results:

  • Psoriasis is frequently associated with a wide range of systemic diseases.
  • Immune-mediated pathways are central to the pathogenesis of both psoriasis and its comorbidities.
  • Identifying and managing these interconnected conditions is crucial for patient outcomes.

Conclusions:

  • Psoriasis management requires addressing its numerous comorbidities.
  • Understanding shared immune mechanisms informs treatment strategies.
  • A multidisciplinary approach is vital for comprehensive care of individuals with psoriasis and associated conditions.