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Local release of highly loaded antibodies from functionalized nanoporous support for cancer immunotherapy

Chenghong Lei1, Pu Liu, Baowei Chen

  • 1Pacific Northwest National Laboratory, Richland, Washington 99352, USA. chenghong.lei@pnl.gov

Journal of the American Chemical Society
|May 4, 2010
PubMed

We report that antibodies can be spontaneously loaded in functionalized mesoporous silica (FMS) with superhigh density (0.4-0.8 mg of antibody/mg of FMS) due to their comprehensive noncovalent interaction. The superhigh loading density and noncovalent interaction between FMS and antibodies allow long-lasting local release of the immunoregulatory molecules from FMS under physiological conditions. Preliminary data indicate that FMS-anti-CTLA4 antibody injected directly into a mouse melanoma induces much greater and extended inhibition of tumor growth than the antibody given systemically. Our findings open up a novel approach for local delivery of therapeutically active proteins to tumors and, potentially, other diseases.

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