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Analysis of genes and chromosomes by nonisotopic in situ hybridization
P Lichter1, A L Boyle, T Cremer
1Institute for Viral Research, German Cancer Research Center, Heidelberg.
Genetic Analysis, Techniques and Applications
|February 1, 1991
Abstract:
Nonisotopic in situ hybridization is a powerful tool to analyze the organization of complex genomes. Current approaches utilizing this technique for the analysis of linear and spatial genome organizations are presented. Clinical applications of these approaches, which open new avenues for diagnosis of disease-related chromosomal changes, are also discussed.