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Related Concept Videos

Embryonic Connective Tissues01:20

Embryonic Connective Tissues

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Glycosaminoglycans01:23

Glycosaminoglycans

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

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Related Experiment Video

Updated: Jun 13, 2026

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration
11:16

In Vitro Investigation of the Effects of the Hyaluronan-Rich Extracellular Matrix on Neural Crest Cell Migration

Published on: February 10, 2023

[Hyaluronan, embryogenesis and morphogenesis].

P Vabres1

  • 1Service de Dermatologie, CHU de Dijon, Hôpital du Bocage, BP 77908, 21079 Dijon cedex, France. pierre.vabres@chu-dijon.fr

Annales De Dermatologie Et De Venereologie
|May 4, 2010
PubMed
Summary
This summary is machine-generated.

Hyaluronan, a key extracellular matrix molecule, regulates vertebrate embryonic development by influencing cell migration and transformation. Its synthesis and degradation are critical for preventing developmental anomalies.

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Area of Science:

  • Extracellular matrix biology
  • Developmental biology
  • Glycosaminoglycan research

Background:

  • Hyaluronan is a major carbohydrate component of the extracellular matrix.
  • It plays a crucial role in vertebrate embryogenesis, regulating cell transformation and migration.
  • Hyaluronan is synthesized by hyaluronan synthetases and degraded by hyaluronidases.

Purpose of the Study:

  • To elucidate the regulatory role of hyaluronan in embryonic development.
  • To understand the impact of hyaluronan synthetase activity on developmental processes.
  • To explore the interactions of hyaluronan with cell surface receptors and their signaling pathways.

Main Methods:

  • Analysis of hyaluronan synthetase expression during embryonic development.
  • Investigating the effects of hyaluronan synthetase inactivation or upregulation.
  • Studying hyaluronan binding to cell surface receptors (e.g., CD44, RHAMM).

Main Results:

  • Hyaluronan synthetases are expressed early in embryogenesis, including gastrulation.
  • Altered hyaluronan synthetase activity leads to cardiac and skeletal developmental anomalies.
  • Hyaluronan interacts with cell surface receptors, influencing cell signaling, differentiation, and proliferation.

Conclusions:

  • Hyaluronan plays a central regulatory role during vertebrate embryogenesis.
  • Dysregulation of hyaluronan metabolism can cause significant developmental defects.
  • Hyaluronan's interactions with cell surface receptors are key to its developmental functions.