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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
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Drugs for Treatment of Diarrhea-Predominant IBS

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
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Related Experiment Video

Updated: Jun 13, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic

Terence J Frohmader1, Wendy P Chaboyer, Iain K Robertson

  • 1Intensive Care Unit, Launceston General Hospital, Launceston, Tasmania, Australia. terry.frohmader@dhhs.tas.gov.au

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
|May 4, 2010
PubMed
Summary
This summary is machine-generated.

Multispecies probiotic VSL#3 significantly reduced liquid stool frequency in critically ill patients receiving enteral nutrition. Further trials are needed to confirm probiotics

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Last Updated: Jun 13, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Area of Science:

  • Critical Care Medicine
  • Gastroenterology
  • Microbiology

Background:

  • Diarrhea poses significant risks to critically ill patients, healthcare staff, and healthcare costs.
  • Enteral nutrition is common in intensive care units but can be associated with gastrointestinal complications like diarrhea.

Purpose of the Study:

  • To assess the efficacy of the multispecies probiotic VSL#3 in decreasing liquid stool episodes in enterally fed critically ill patients.
  • To evaluate the impact of VSL#3 on stool frequency and weight in this patient population.

Main Methods:

  • A single-center, double-blind, randomized, placebo-controlled pilot study.
  • 45 critically ill adults requiring enteral nutrition for over 72 hours received either VSL#3 or placebo twice daily.
  • Stool frequency and weight were measured for liquid stool and liquid/unformed stool.

Main Results:

  • No demographic or clinical differences were observed between the VSL#3 and placebo groups.
  • The VSL#3 group showed a significant reduction in the frequency of liquid stools (IRR 0.50, P = .03).
  • Significant reductions were also noted in the frequency and weight of liquid and unformed stools in the VSL#3 group compared to placebo.

Conclusions:

  • VSL#3 demonstrated effectiveness in reducing liquid stool frequency in critically ill patients on enteral nutrition.
  • Probiotics may offer a strategy to mitigate diarrhea in tube-fed critically ill patients.
  • Further controlled clinical trials are warranted to validate these findings.