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Updated: Jun 13, 2026
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Biotechnological production and application of ganoderic acids
Jun-Wei Xu1, Wei Zhao, Jian-Jiang Zhong
1Key Laboratory of Microbial Metabolism (Ministry of Education), School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai, 200240, China.
Applied Microbiology and Biotechnology
|May 4, 2010
Summary
Ganoderic acids (GAs) from Ganoderma lucidum show significant pharmacological effects. Research focuses on optimizing submerged fermentation to enhance GA production and exploring their applications.
Area of Science:
- Biochemistry
- Pharmacology
- Mycology
Background:
- Ganoderic acids (GAs) are bioactive triterpenoids found in Ganoderma lucidum.
- GAs exhibit notable pharmacological functions, attracting research interest.
- Submerged fermentation is a key technology for GA production.
Purpose of the Study:
- To review recent advancements in the fermentative production of Ganoderic acids.
- To summarize progress in manipulating fermentation conditions and bioprocessing strategies for enhanced GA yield.
- To outline the biosynthetic pathway of GAs.
Main Methods:
- Review of recent scientific publications on Ganoderic acid production.
- Analysis of fermentation process development strategies.
- Summary of bioprocessing techniques for Ganoderma lucidum.
Main Results:
- Significant efforts have been made in optimizing fermentation conditions for higher GA yields.
- Various bioprocessing strategies have been developed to improve G. lucidum fermentation.
- The biosynthetic pathway of GAs has been elucidated.
Conclusions:
- Fermentative production of GAs is a promising avenue for their large-scale synthesis.
- Continued research into fermentation optimization and bioprocessing is crucial for maximizing GA production.
- Understanding the biosynthetic pathway aids in genetic and metabolic engineering approaches.
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