Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Storage01:23

Storage

A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze each...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Working Memory01:24

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.
Visual Agnosia01:12

Visual Agnosia

Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round end"...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A longitudinal study of partner support and maternal mental health following pregnancy during public health crises.

Journal of affective disorders·2026
Same author

Impact of childhood adversity on deep brain stimulation outcomes for treatment resistant depression.

Psychiatry research·2026
Same author

The effect of state anxiety on jumping-to-conclusions bias in social anxiety: An experimental and computational modelling study.

Behaviour research and therapy·2025
Same author

Schizotypy, Schizotypal Personality Disorder and Eating Disorders: A Systematic Review.

Clinical psychology & psychotherapy·2025
Same author

Investigating the neuropsychological features of hoarding disorder using a novel virtual reality paradigm.

Cognitive neuropsychiatry·2025
Same author

Misprediction Sensitivity Is Diminished for Action-effects Resulting from Stimulus-driven Movement.

Journal of cognitive neuroscience·2025

Related Experiment Video

Updated: Jun 13, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

Visual-spatial episodic memory in schizophrenia: A multiple systems framework.

Todd A Girard1, Bruce K Christensen2, Michael G DeGroote3

  • 1Department of Psychology, Ryerson University.

Neuropsychology
|May 5, 2010
PubMed
Summary

Individuals with schizophrenia show significant deficits in allocentric and event-based visual-spatial memory. These findings highlight potential therapeutic strategies focusing on egocentric representations for improved navigation and memory in daily life.

More Related Videos

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise
06:17

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jun 13, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise
06:17

Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

Published on: January 26, 2024

Area of Science:

  • Cognitive Neuroscience
  • Psychiatry
  • Translational Research

Background:

  • Schizophrenia is associated with cognitive deficits, including impairments in visual-spatial memory.
  • Understanding the neurobiological underpinnings of these deficits is crucial for developing effective treatments.
  • Translational research using cross-species comparable methods can enhance our understanding of cognitive disorders.

Purpose of the Study:

  • To investigate visual-spatial memory abilities in individuals with schizophrenia-spectrum disorders using a translational framework.
  • To examine specific dimensions of visual-spatial memory, including spatial location vs. object memory, allocentric vs. egocentric representations, and event vs. reference memory.

Main Methods:

  • A human analog of rodent maze tasks, the 'bin task', was employed.
  • Participants (30 with schizophrenia, 30 healthy controls) hid and retrieved objects from visually identical bins after a delay.
  • Visual-spatial memory was assessed across allocentric/egocentric and event/reference memory dimensions.

Main Results:

  • The schizophrenia group exhibited significant deficits in recalling spatial locations under allocentric viewing conditions compared to controls (p = .005, d = -0.77).
  • Deficits were also pronounced for event memory (working memory) in the schizophrenia group (p = .004, d = -0.77).
  • No significant differences were found for egocentric spatial memory (p = .298, d = -0.28) or reference memory (p = .171, d = -0.33).

Conclusions:

  • The findings support the hypothesis of preferential deficits in hippocampal-mediated memory systems in schizophrenia.
  • The bin task serves as a valuable paradigm for translational research in cognitive disorders.
  • Individuals with schizophrenia may benefit from mnemonic strategies emphasizing egocentric spatial representations and consistency.