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Related Experiment Video

Updated: Jun 13, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Burn scar carcinoma.

Chun-Yuan Huang¹, Chung-Ho Feng, Yen-Chang Hsiao

¹LinKou Burn Center, Department of Plastic & Reconstructive Surgery, Chang Gung Memorial Hospital and University, Taipei, Taiwan.

The Journal of Dermatological Treatment

|May 5, 2010

Summary

Marjolin ulcer, or malignant changes in burn scars, is often squamous cell carcinoma (SCC). Early wound care and aggressive treatment are crucial for preventing advanced scar cancer and improving patient prognosis.

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Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

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Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

Area of Science:

Dermatology
Oncology
Surgical Pathology

Background:

Marjolin ulcer, malignant transformation in burn scars, has been documented since 1828.
Few reports exist on Marjolin ulcer incidence in Oriental populations.
Burn scar carcinoma predominantly affects extremities.

Observation:

A study at Chang Gung Memorial Hospital identified 11 burn scar carcinoma cases between 1989 and 2008.
The majority of cases were squamous cell carcinoma (SCC), with one verrucous carcinoma.
Most patients underwent surgical intervention, including excision, grafting, or amputation.

Findings:

Prognosis for advanced scar cancer is poor, with risks of recurrence and metastasis.
Six patients remained tumor-free post-treatment, while five were lost to follow-up.
Squamous cell carcinoma is the most common type of scar malignancy.

Implications:

Aggressive initial burn wound care, including early grafting and diligent scar management, is vital for prevention.
Preventing repeated ulceration in burn scars can reduce the incidence of malignancy.
Timely surgical intervention and regular patient follow-up are essential for managing burn scar carcinoma.