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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

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Multidisciplinary Approach to Obesity Management: A Case Report

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[Can an obese patient be metabolically normal?].

Z Pataky¹, E Bobbioni-Harsch, V Makoundou

¹Service d'enseignement thérapeutique pour maladies chroniques, Centre collaborateur de l'OMS, Département de médecine communautaire, HUG, Genève 14. zoltan.pataky@hcuge.ch

Revue Medicale Suisse

|May 6, 2010

Summary

Obesity poses cardiovascular risks, even when traditional metabolic markers appear normal. Excess body weight is the primary driver of obesity

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Area of Science:

Cardiology and Metabolic Health
Obesity Medicine and Public Health

Context:

Obesity is a known cardiovascular risk factor linked to cardio-metabolic diseases.
The concept of 'metabolically benign' or 'uncomplicated' obesity is debated.
Defining metabolic normality in obese individuals presents challenges, particularly regarding borderline normal parameter ranges.

Purpose:

To review and synthesize current understanding of metabolic normality in individuals with obesity.
To clarify the criteria and parameters used to assess metabolic health in overweight and obese populations.

Summary:

Studies reveal that even with seemingly normal traditional cardio-metabolic markers (lipid profile, glycemia, blood pressure), individuals with overweight or obesity differ from normal-weight individuals.
These differences often manifest as parameters existing at the upper limit of the normal range.
The article concludes that excess body weight is the most significant factor contributing to the cardio-metabolic complications associated with obesity.

Impact:

Highlights the critical role of body weight in obesity-related cardiovascular and metabolic dysfunction.
Informs clinical practice regarding the assessment and management of metabolic health in obese patients.
Contributes to public health strategies emphasizing weight management for cardiovascular disease prevention.