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Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Updated: Jun 13, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

[Obesity in the elderly: which attitude?].

S Buclin Thiébaud¹, Z Pataky, A Golay

¹Service d'enseignement thérapeutique pour maladies chroniques, Centre collaborateur de l'OMS, Département de médecine communautaire et de premier recours, HUG, 1211 Genève 14. severine.buclin@hcuge.ch

Revue Medicale Suisse

|May 6, 2010

Summary

Weight loss in elderly requires caution due to lean mass reduction. However, for obese seniors, it can improve mobility and reduce cardio-metabolic risks with a balanced diet and exercise.

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Multidisciplinary Approach to Obesity Management: A Case Report

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Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

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Published on: July 5, 2017

Area of Science:

Gerontology
Body Composition Analysis
Obesity Management

Context:

Aging leads to decreased lean body mass and increased visceral fat.
Weight loss in older adults can reduce lean mass, necessitating careful management.
Obesity in the elderly is linked to cardio-metabolic complications and reduced mobility.

Purpose:

To propose a balanced, slightly hypocaloric diet and moderate physical activity plan for elderly patients.
To outline strategies for managing obesity in older adults, including cognitive behavioral approaches and pharmacotherapy.

Summary:

Aging alters body composition, increasing visceral fat and decreasing lean mass.
Weight loss in the elderly must be approached cautiously to preserve lean body mass.
For obese elderly individuals, weight loss is crucial for mitigating health risks and enhancing quality of life, particularly mobility.

Impact:

Provides a framework for safe and effective weight management in the elderly population.
Highlights the dual approach needed for elderly weight loss: caution regarding lean mass and benefits for obesity-related conditions.
Supports improved health outcomes and quality of life for aging individuals struggling with obesity.