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Updated: Jun 13, 2026

A Miniaturized Glycan Microarray Assay for Assessing Avidity and Specificity of Influenza A Virus Hemagglutinins
Published on: May 29, 2016
Postreassortment amino acid substitutions in influenza A viruses
1Institute of Virology, Russian Academy of Medical Siences, Gamaleya Str. 16, Moscow 123098, Russia. labphysvir@mail.ru
Abstract:
The genome of the influenza A virus consists of eight single-stranded negative sense RNA segments. Segmentation allows reassortment of genes between influenza A virus strains when two strains infect one host cell. Reassortment may lead to the emergence of pandemic influenza viruses. The process of reassortment is limited by the necessity of a functional balance among viral genes. The nature of the functional constraint on reassortment is currently not well understood. An insight into the basis of functional matching of virus genes, its restrictions and its restoration after reassortment may be provided by the analysis of postreassortment mutations in model systems. This article summarizes the data on postreassortment amino acid changes in virus glycoproteins and polymerase proteins and their effect on the intergenic functional match.
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