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Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Left ventricular hypertrophy influences cardiac prognosis in patients undergoing dobutamine cardiac stress testing

Charaslak Charoenpanichkit1, Timothy M Morgan, Craig A Hamilton

  • 1Departments of Internal Medicine Cardiology Section, Public Health Sciences, Biomedical Engineering, and Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, USA.

Circulation. Cardiovascular Imaging
|May 6, 2010
PubMed

Insights

Left ventricular hypertrophy (LVH) predicts myocardial infarction (MI) and cardiac death in patients undergoing dobutamine stress tests. Reporting LVH is crucial, especially for patients without inducible ischemia, to refine cardiac risk assessment.

Area of Science:

  • Cardiology
  • Diagnostic Imaging
  • Cardiac Physiology

Background:

  • Chest pain is a common symptom requiring accurate diagnosis.
  • Left ventricular hypertrophy (LVH) is a structural heart change that may impact cardiac prognosis.
  • Dobutamine stress testing is used to evaluate patients with suspected or known coronary artery disease.

Purpose of the Study:

  • To assess the predictive value of dobutamine stress test findings for myocardial infarction (MI) and cardiac death.
  • To determine if left ventricular hypertrophy (LVH) independently predicts adverse cardiac events.
  • To evaluate the utility of dobutamine stress testing in patients with chest pain and LVH.

Main Methods:

  • 353 participants with chest pain underwent dobutamine cardiovascular magnetic resonance (CMR) stress testing.
  • Participants were followed for a mean of 6 years to track MI or cardiac death.
  • Left ventricular (LV) mass was measured, with LVH defined by sex-specific mass index criteria.

Main Results:

  • LVH was present in 17-18% of participants.
  • 20% of participants experienced MI or cardiac death during follow-up.
  • LVH was an independent predictor of MI and cardiac death (HR=1.99, P=0.02) in multivariable analysis, even in the presence of ischemia.

Conclusions:

  • Left ventricular hypertrophy (LVH) is a significant predictor of future MI and cardiac death.
  • LVH should be reported in dobutamine stress test results, particularly for patients without inducible ischemia.
  • Identifying LVH can help refine risk stratification and patient management.
Abstract

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