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Vaccination despite thimerosal sensitivity.

W Aberer1

  • 1Department of Dermatology I, University of Vienna, Austria.

Contact Dermatitis
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Thimerosal sensitivity is common in Austria, often linked to vaccinations. However, intramuscular (IM) immunizations with thimerosal-containing vaccines are safe for sensitized individuals, with no adverse effects observed.

Area of Science:

  • Immunology
  • Dermatology
  • Public Health

Background:

  • Thimerosal sensitivity is a prevalent contact allergen in Austria, second only to nickel.
  • The incidence of thimerosal sensitivity is increasing, likely associated with frequent vaccinations.

Purpose of the Study:

  • To investigate the relationship between thimerosal sensitivity and vaccinations.
  • To determine the safety of intramuscular (IM) immunizations with thimerosal-containing vaccines in sensitized individuals.

Main Methods:

  • Retrospective questioning of patients with thimerosal-positive patch tests regarding recent immunizations.
  • Prospective study involving IM immunization of 12 thimerosal-sensitized individuals.

Main Results:

Related Experiment Videos

  • Most patients with thimerosal sensitivity had recent vaccinations, with no other exposure sources identified.
  • Subcutaneous administration, not IM, was associated with local reactions in two patients.
  • No side effects were observed in 12 thimerosal-sensitized individuals receiving IM immunizations.

    • Conclusions:

    • Vaccinations are a likely source of thimerosal sensitization.
    • Intramuscular administration of thimerosal in vaccines does not elicit clinical symptoms in sensitized individuals.
    • Thimerosal patch-test positivity is not a contraindication for IM immunization with thimerosal-containing vaccines.