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Updated: Jun 13, 2026

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Published on: September 5, 2016
Thrombotic microangiopathies: multimers, metalloprotease, and beyond
1Rice University, Houston, Texas, USA. jmoake@rice.edu
Abstract:
The pathophysiology of various types of thrombotic microangiopathies is coming progressively into focus. Therapeutic advances are likely to follow at a quickening pace. This discussion focuses on thrombotic thrombocytopenic purpura (TTP), the hemolytic-uremic syndrome (HUS), thrombotic microangiopathies associated with transplantation-immunosuppression or anti-angiogenesis therapy, and the preeclampsia/hemolysis-elevated liver enzymes and low platelets syndrome (HELLP).
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