Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic nervous dysfunction in essential hypertension.

S Julius1

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0356.

Diabetes Care
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lowering Albuminuria-Does It Lower the Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Reducing Microalbuminuria-Does It Lower Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

AGRICULTURAL BEST MANAGEMENT PRACTICE SENSITIVITY TO CHANGING AIR TEMPERATURE AND PRECIPITATION.

Transactions of the ASABE·2021
Same author

Toward indicators of the performance of US Infrastructures under climate change risks.

Climatic change·2021
Same author

Namaqualand hip dysplasia in South Africa: The molecular determinant elucidated.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

Relationships between metrics of visit-to-visit variability of blood pressure.

Journal of human hypertension·2013
Same journal

A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes.

Diabetes care·2026
Same journal

Clinical and Biochemical Recovery From Immune Checkpoint Inhibitor-Induced Diabetes With Seroconversion of GAD Antibodies.

Diabetes care·2026
Same journal

State Insulin Out-of-Pocket Cap Policies and Estimated Eligible Populations in the United States, 2019-2026.

Diabetes care·2026
Same journal

Genetic Determinants of Macronutrient Intake Are Associated With Specific Food Intake in Youth: A Cohort Study Across Childhood and Adolescence.

Diabetes care·2026
Same journal

A Novel Electronic Medical Record Search Method to Identify Patients With Ketosis-Prone Diabetes: Implications for Discovery of Atypical Diabetes.

Diabetes care·2026
Same journal

Real-Time Continuous Glucose Monitoring Among People With Type 2 Diabetes and End-Stage Kidney Failure Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.

Diabetes care·2026
See all related articles

Borderline hypertension, characterized by fluctuating blood pressure, is linked to increased sympathetic nervous system activity. This condition predicts future severe hypertension and is associated with metabolic issues like obesity and insulin resistance.

Area of Science:

  • Cardiovascular Physiology
  • Neuroendocrinology
  • Metabolic Syndrome

Background:

  • Borderline hypertension, a precursor to established hypertension, exhibits distinct pathophysiological mechanisms.
  • Patients often present with elevated cardiac output and normal vascular resistance, differing from established hypertension.
  • This condition is characterized by a neurogenically driven increase in cardiac output, modulated by autonomic nervous system activity.

Purpose of the Study:

  • To elucidate the pathophysiological differences between borderline and established hypertension.
  • To investigate the role of the sympathetic nervous system in borderline hypertension and its transition to established hypertension.
  • To explore the association between borderline hypertension and metabolic abnormalities.

Main Methods:

Related Experiment Videos

  • Hemodynamic assessments including cardiac output and vascular resistance measurements.
  • Autonomic blockade studies to evaluate the neurogenic component of elevated cardiac output.
  • Analysis of sympathetic and parasympathetic tone in patients with borderline hypertension.

Main Results:

  • Borderline hypertension is characterized by elevated cardiac output due to increased sympathetic drive, which can be reversed by autonomic blockade.
  • Patients exhibit increased sympathetic tone to the kidneys, arterioles, and veins, alongside decreased parasympathetic tone.
  • Transition to established hypertension involves vascular hypertrophy and a shift towards high vascular resistance, despite a seemingly normalized sympathetic tone.

Conclusions:

  • The sympathetic nervous system plays a crucial role in both borderline and established hypertension, even when its tone appears normalized.
  • Borderline hypertension is linked to metabolic abnormalities, suggesting a common pathophysiological basis possibly related to increased sympathetic drive.
  • Understanding these mechanisms offers insights into the interconnectedness of hypertension and metabolic diseases like diabetes mellitus.