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O2 uptake in hyperthyroidism during constant work rate and incremental exercise.

I Ben-Dov1, K E Sietsema, K Wasserman

  • 1Department of Medicine, Harbor-UCLA Medical Center, Torrance 90509.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1991
PubMed
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Hyperthyroidism increases resting and steady-state oxygen uptake (VO2) and alters the VO2 response during exercise transitions. This suggests impaired oxygen kinetics in hyperthyroid patients compared to healthy individuals.

Area of Science:

  • Cardiopulmonary exercise physiology
  • Endocrinology

Background:

  • Hyperthyroidism is associated with increased metabolic rate.
  • The impact of hyperthyroidism on oxygen uptake (VO2) kinetics during exercise is not fully understood.

Purpose of the Study:

  • To investigate the effect of hyperthyroidism on the pattern and time course of oxygen uptake (VO2) following the transition from rest to exercise.

Main Methods:

  • Six hyperthyroid patients and six healthy controls performed cycle exercise at constant work rates.
  • Cardiorespiratory variables, including VO2, were measured breath-by-breath.
  • Patients also underwent a progressively increasing work rate test, with two repeating tests when euthyroid.

Main Results:

  • Resting and steady-state VO2 were higher in hyperthyroid patients than controls.

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  • The initial VO2 increase during exercise (phase I) was lower in patients, while the time to reach steady-state VO2 (phase II half-time) showed no significant difference.
  • The oxygen cost per work rate increment (delta VO2/delta WR) was within normal limits, but higher in hyperthyroid versus euthyroid states.

    • Conclusions:

    • Hyperthyroidism elevates resting and steady-state VO2 and alters the dynamic VO2 response during exercise onset.
    • Despite normal oxygen cost per work rate, the overall oxygen utilization is affected by hyperthyroidism.