Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated HER2 Scoring with Uncertainty Quantification Using Lensfree Holography and Deep Learning.

BME frontiers·2026
Same author

Snapshot 3D image projection using a diffractive decoder.

Light, science & applications·2026
Same author

Autonomous Uncertainty Quantification for Computational Point-of-Care Sensors.

ACS nano·2026
Same author

Universal and transferable attacks on pathology foundation models using microscopic perturbations.

Light, science & applications·2026
Same author

Super-resolution image projection over an extended depth of field using a diffractive decoder.

Light, science & applications·2026
Same author

Deep learning-enhanced dual-mode multiplexed optical sensor for point-of-care diagnostics of cardiovascular diseases.

Light, science & applications·2026

Related Experiment Video

Updated: Jun 13, 2026

Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone
06:42

Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone

Published on: April 11, 2013

Lensfree microscopy on a cellphone.

Derek Tseng1, Onur Mudanyali, Cetin Oztoprak

  • 1UCLA Electrical Engineering Department, University of California, Los Angeles, CA 90095, USA.

Lab on a Chip
|May 7, 2010
PubMed
Summary
This summary is machine-generated.

A new lensfree cellphone microscope offers a cost-effective, portable solution for telemedicine. This compact holographic imaging device reconstructs microscopic images from cellphone-captured holograms, aiding global health challenges.

More Related Videos

Lensless Fluorescent Microscopy on a Chip
11:23

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics
08:19

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

Published on: December 14, 2009

Related Experiment Videos

Last Updated: Jun 13, 2026

Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone
06:42

Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone

Published on: April 11, 2013

Lensless Fluorescent Microscopy on a Chip
11:23

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics
08:19

Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

Published on: December 14, 2009

Area of Science:

  • Biomedical Engineering
  • Optical Physics
  • Digital Imaging

Background:

  • Microscopy is crucial for diagnostics but often requires expensive, bulky equipment.
  • Telemedicine applications require portable, low-cost imaging solutions.

Purpose of the Study:

  • To demonstrate a lensfree holographic microscope integrated with a cellphone.
  • To assess its potential as a cost-effective tool for telemedicine and global health.

Main Methods:

  • A compact, lensfree holographic microscope was developed and attached to a cellphone.
  • Samples were illuminated by an LED, generating holograms on the cellphone's camera.
  • Microscopic images were reconstructed using digital processing of holographic signatures.

Main Results:

  • The device successfully imaged micro-particles, red blood cells, white blood cells, platelets, and Giardia lamblia.
  • The lensfree microscope is lightweight (approx. 38g) and requires no bulky optical components.
  • Holographic signatures captured by the cellphone enabled rapid image reconstruction.

Conclusions:

  • Lensfree cellphone microscopy presents a viable, low-cost alternative for point-of-care diagnostics.
  • This technology has significant potential for telemedicine and addressing global health disparities.
  • Further development could expand its applications in various biomedical fields.