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Updated: Jun 13, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Different spatial memory systems are involved in small- and large-scale environments: evidence from patients with
L Piccardi1, A Berthoz, M Baulac
1Dipartimento di Scienze della Salute, Università degli Studi dell'Aquila, Via Vetoio, Coppito 2 (AQ), Italy. laura.piccardi@cc.univaq.it
Abstract:
Recent reports show that humans and animals do not acquire information about routes and object locations in the same way. In spatial memory, a specific sub-system is hypothesized to be involved in encoding, storing and recalling navigational information, and it is segregated from the sub-system devoted to small-scale environment. We assessed this hypothesis in a sample of patients treated surgically for intractable temporal lobe epilepsy. We found double dissociations between learning and recall of spatial positions in large space versus small space. These results strongly support the hypothesis that two segregate systems process navigational memory for large-scale environments and spatial memory in small-scale environments.
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