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Updated: Jun 13, 2026

Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues
02:35

Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues

Published on: March 22, 2024

[Cheek paresthesia by an osteosarcoma].

S K B Veldhuis1, M J H Witjes, H Reintsema

  • 1Centrum voor Tandheelkunde en Mondzorgkunde, Universitair Medisch Centrum Groningen, Groningen. s.veldhuis@kchir.umcg.nl

Nederlands Tijdschrift Voor Tandheelkunde
|May 8, 2010
PubMed
Summary
This summary is machine-generated.

A rare maxillary osteosarcoma in a young woman was successfully treated with chemotherapy and surgery. This case highlights the effectiveness of combined treatment for head and neck osteosarcomas.

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Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues
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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Area of Science:

  • Oral and Maxillofacial Surgery
  • Oncology
  • Pathology

Background:

  • Osteosarcoma is a rare malignant bone tumor, with approximately 10% occurring in the head and neck region.
  • Maxillary osteosarcomas, though less common than mandibular ones, present significant diagnostic and therapeutic challenges.

Observation:

  • A 21-year-old female presented with a hard, elastic cheek swelling and local paresthesia.
  • Histopathologic and radiographic examinations confirmed an osteosarcoma in the left maxilla.

Findings:

  • The patient underwent neoadjuvant chemotherapy, radical surgical resection, and adjuvant chemotherapy.
  • One-year follow-up showed no evidence of local recurrence or distant metastases, indicating successful treatment.

Implications:

  • This case underscores the importance of multidisciplinary management for maxillary osteosarcomas.
  • The combination of surgery and (neo)adjuvant chemotherapy appears beneficial, warranting further research into optimal treatment protocols.