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Extraction: Advanced Methods

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...

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Related Experiment Video

Updated: Jun 13, 2026

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Published on: August 28, 2017

Droplet-based microextraction in the aqueous two-phase system.

Young Hoon Choi¹, Young Soo Song, Do Hyun Kim

¹Department of Chemical and Biomolecular Engineering and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea.

Journal of Chromatography. A

|May 8, 2010

Summary

This summary is machine-generated.

This study demonstrates droplet-based microextraction using aqueous two-phase systems in microfluidic devices. Researchers successfully measured ruthenium red concentration and controlled droplet movement for efficient chemical extraction.

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Last Updated: Jun 13, 2026

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Aqueous Droplets Used as Enzymatic Microreactors and Their Electromagnetic Actuation

Published on: August 28, 2017

Fabricating High-viscosity Droplets using Microfluidic Capillary Device with Phase-inversion Co-flow Structure

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Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

Area of Science:

Analytical Chemistry
Microfluidics
Chemical Engineering

Background:

Microfluidic systems offer precise control over chemical processes.
Droplet-based systems enable efficient mass transfer and sample manipulation.
Aqueous two-phase systems are effective for liquid-liquid extraction.

Purpose of the Study:

To demonstrate droplet-based microextraction using aqueous two-phase systems in a microfluidic device.
To analyze mass transport phenomena during microextraction.
To showcase electrohydrodynamic control for droplet manipulation and process termination.

Main Methods:

Generation of aqueous two-phase system droplets using an electrohydrodynamic method.
Microextraction of ruthenium red within the microfluidic device.
Quantification of ruthenium red concentration via digital image analysis.
Numerical analysis of mass transport using a diffusion-dissolution model.

Main Results:

Successful demonstration of microextraction of ruthenium red.
Measured ruthenium red concentration showed good agreement with a diffusion model.
Achieved a maximum partition coefficient of 9.58.
Electrohydrodynamic manipulation enabled controlled termination of microextraction and droplet sorting.

Conclusions:

Droplet-based microextraction in microfluidic systems is a viable technique.
The developed method allows for real-time concentration measurement and controlled process termination.
This approach has potential for integrated microfluidic chemical analysis and synthesis.