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Correlation between plasma asymmetric dimethylarginine and different types of coronary heart disease

Yu Cao1, Kan Yang, Zhihui Zhang

  • 1Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|May 8, 2010
PubMed

Insights

Plasma asymmetric dimethylarginine (ADMA) levels are elevated in patients with acute coronary syndrome (ACS), suggesting ADMA may serve as a key biomarker for ACS and related heart conditions.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Clinical Chemistry

Background:

  • Coronary heart disease (CHD) encompasses stable angina pectoris (SAP) and acute coronary syndrome (ACS).
  • Endothelial dysfunction plays a critical role in the pathogenesis of CHD.
  • Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase, impacting endothelial function.

Purpose of the Study:

  • To investigate plasma levels of ADMA, nitric oxide (NO), and von Willebrand factor (vWF) in patients with SAP and ACS.
  • To determine the correlation between ADMA levels and the presence of SAP or ACS.

Main Methods:

  • A cohort of 143 subjects was categorized into non-CHD, SAP, and ACS groups.
  • Plasma concentrations of ADMA, NO, and vWF were measured in all participants.
  • Statistical analyses were performed to correlate biomarker levels with CHD status.

Main Results:

  • ADMA levels were significantly higher in the ACS group compared to non-CHD and SAP groups (P<0.05).
  • NO levels were decreased in both SAP and ACS groups, with a more pronounced reduction in ACS.
  • vWF levels were elevated in both SAP and ACS groups compared to the non-CHD group.

Conclusions:

  • Elevated plasma ADMA levels are strongly associated with acute coronary syndrome.
  • ADMA shows potential as a valuable clinical marker for the diagnosis and management of ACS.
Abstract

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