Related Experiment Video
Updated: Jun 13, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Cerebral vasculitis associated with amyloid angiopathy: case report
Masaki Morishige1, Tatsuya Abe, Tohru Kamida
1Department of Neurosurgery, Oita University School of Medicine, Yufu, Oita, Japan.
Abstract:
A 78-year-old female presented with coexisting primary angiitis of the central nervous system (CNS) and cerebral amyloid angiopathy (CAA) manifesting as motor aphasia caused by a left frontal lobe lesion. Magnetic resonance imaging revealed an enhanced lesion with moderate surrounding edema.Technetium-99m propylene amine oxime single-photon emission computed tomography showed decreased cerebral blood flow (CBF) in the lesions, and high serum soluble-interleukin-2 level was detected, suggesting intravascular lymphoma of the CNS. Cerebral biopsy revealed CAA with secondary florid vasculitic appearance. The CBF and neurological symptoms, such as aphasia and dementia, recovered following steroid treatment. Cerebral vasculitis associated with CAA should be included in the differential diagnosis of an unusually enhanced lesion, because timely diagnosis and aggressive treatment are critical to successful recovery in such elderly patients.
Related Concept Videos
Cerebral Edema ll: Pathophysiology
Dementia l: Introduction
Encephalitis ll: Pathophysiology
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Cerebral Edema l: Introduction
Hemorrhagic Stroke l: Introduction

