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Updated: Jun 13, 2026
08:43
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
[Annular rectal constriction caused by infiltrating bladder carcinoma: a case report].
Hiromichi Katayama1, Koji Mituzuka, Yoshihide Kawasaki
1Department of Urology, Ogachi-Chuo Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|May 8, 2010
Summary
This case study details a 64-year-old man with advanced urothelial carcinoma. Despite radical surgery and chemotherapy, the cancer metastasized, leading to rectal involvement and a fatal outcome.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- A 64-year-old male presented with gross hematuria and urinary frequency.
- Initial investigations revealed a bladder tumor involving the left ureteral orifice.
Observation:
- Computed tomography and MRI confirmed a bladder tumor extending beyond the bladder wall with left hydronephrosis.
- Transurethral biopsy diagnosed grade 3 urothelial carcinoma with glandular differentiation and signet ring cells.
Findings:
- Radical surgery (cystectomy, nephrureterectomy) was performed, with pathological staging of pT3aN0.
- The patient experienced lymph node metastasis five months post-surgery.
- M-VAC chemotherapy showed limited efficacy, and rectal wall thickening was noted 16 months later.
Implications:
- This case highlights the aggressive nature of high-grade urothelial carcinoma with signet ring cell features.
- The limited response to M-VAC chemotherapy underscores the challenges in treating advanced bladder cancer.
- The progression to distant metastasis and rectal involvement indicates a poor prognosis despite aggressive treatment.
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