Synthesis of polycaprolactone: a review

Area of Science:

• Polymer Chemistry
• Materials Science

Background:

• Polycaprolactone (PCL) is a key biodegradable polymer.
• PCL offers excellent mechanical properties and miscibility with other polymers.
• Two primary synthesis routes exist: polycondensation and ring-opening polymerization (ROP).

Purpose of the Study:

• To critically review PCL synthesis methods.
• To provide an overview of diverse catalytic systems used in PCL production.
• To emphasize the ROP pathway for superior polymer outcomes.

Main Methods:

• Literature review of PCL synthesis conditions.
• Categorization of catalytic systems (enzymatic, organic, metal-based).
• Presentation of reaction mechanisms and conditions.

Main Results:

• Extensive variety of catalysts explored across the periodic table.
• Detailed lists of reaction conditions, catalysts, and initiators provided.
• ROP pathway highlighted for its prevalence and polymer quality.

Conclusions:

• ROP of epsilon-caprolactone is the preferred method for PCL synthesis.
• A wide array of catalytic systems can be employed for PCL production.
• The review serves as a comprehensive resource for PCL synthesis research.