Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction
1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA. akghosh@purdue.edu
Chemical Communications (Cambridge, England)
|May 8, 2010
Abstract:
We have developed a practical synthesis of unique nucleoside derivatives via TiCl(4) promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation.
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