Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Humanizing "multimodal" digital phenotyping of serious mental illness.

Journal of psychopathology and clinical science·2026
Same author

Speech under stress: Affective and cognitive reactivity in schizophrenia and their functional correlates.

Schizophrenia research. Cognition·2026
Same author

Schizotypal traits and daily social functioning: Insights from ecological momentary assessment.

Schizophrenia research·2026
Same author

A Single, Interpretable Vocal Biomarker for Enriching Antipsychotic Clinical Trials.

Biological psychiatry·2025
Same author

Speech pause and speech rate for evaluating Alzheimer's and mild cognitive impairment: A meta-analysis.

Journal of the International Neuropsychological Society : JINS·2025
Same author

Disorganization and disintegration in schizophrenia: Metacognitive capacity across levels of conceptual disorganization.

Schizophrenia research·2025

Related Experiment Video

Updated: Jun 13, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

A framework for understanding experiential deficits in schizophrenia.

Alex S Cohen1, Kyle S Minor, Gina M Najolia

  • 1Louisiana State University, Department of Psychology, 236 Audubon Hall, Baton Rouge, Louisiana 70803, USA. acohen@lsu.edu

Psychiatry Research
|May 11, 2010
PubMed
Summary

Schizophrenia involves emotional deficits through two distinct pathways: "ambivalence" with intact pleasure and heightened negative emotions, or "apathy" with anhedonia and reduced negative emotions. Understanding these differences is key for effective treatment.

More Related Videos

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Related Experiment Videos

Last Updated: Jun 13, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Area of Science:

  • Neuroscience
  • Psychology
  • Psychiatry

Background:

  • Schizophrenia is linked to emotional/motivational deficits and functional impairments.
  • Schizophrenia's heterogeneity complicates understanding these emotional disruptions.
  • Existing research necessitates integrating findings across disciplines.

Purpose of the Study:

  • To propose a dual-pathway model for emotional deficits in schizophrenia.
  • To differentiate between "ambivalence" and "apathy" pathways.
  • To guide future research on negative affect in schizophrenia.

Main Methods:

  • Literature synthesis integrating schizophrenia, neuroscience, and psychology.
  • Hypothesis formulation based on existing empirical data.
  • Conceptual framework development.

Main Results:

  • Emotional deficits in schizophrenia may arise from two distinct pathways: "ambivalence" or "apathy".
  • "Ambivalence" pathway: Intact hedonic capacity with co-activated negative emotions.
  • "Apathy" pathway: Anhedonia with sparse negative emotions.

Conclusions:

  • The proposed dual-pathway model offers a novel framework for understanding schizophrenia's emotional deficits.
  • Distinguishing between these pathways is crucial for targeted interventions.
  • Future research should focus on the differential manifestation of negative affect and its consequences.